I want to do the same thing. I like to use both, and right now, I have to manually enable them both. You CAN do location-based things, as @rbruceporter showed. But there are two problems with tying Wyze to Alexa’s away mode. One is that Wyze doesn’t have shortcuts/rules tied to Alexa routines at all yet. (I hope that’s coming soon)
The other problem, which is out of Wyze’s hands, is that Alexa doesn’t currently support tying ANY routine to away mode. I have to imagine they’ll change that soon, as it seems so obvious. But I can’t even make Alexa turn off my lights when I say “Alexa, I’m leaving” unless I override the default “Alexa, I’m leaving” functionality entirely.
I did manage to work around that (turning out lights, etc) by making a separate Alexa routine. First, I say “Hey Alexa. Bye.” That triggers a routine. Alexa says “Goodbye,” then turns off my lights after 60 seconds. After that, Alexa says “Okay, Google. Bye.” Then my Google Home replies “Hey Alexa, I’m leaving,” which then activates Alexa Guard. Haha. It’s a stupid workaround, but it works.
If Wyze could tie shortcuts to Alexa, everything would work perfectly as I want.